Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress
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چکیده
منابع مشابه
Stress-induced sickness behaviors: an alternative hypothesis for responses during maternal separation.
During maternal separation, some primate and nonprimate species show a biphasic (active/passive) response. The second stage is characterized by reduced activity, a hunched body posture, and other behaviors. Traditionally, the second stage has been referred to as "despair" and is considered an animal model for human depression. Recent research in psychoneuroimmunology suggests an alternative hyp...
متن کاملEarly Maternal Influences on Stress Circuitry: Implications for Resilience and Susceptibility to Physical and Mental Disorders
1 Traumatic Stress Studies Division, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 2 Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA 3 Laboratory of Molecular Neuropsychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 4 Department of Neuroscience, Icahn School of ...
متن کاملNeonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat.
This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) on postnatal days 2-14 or 2) no handling or separation (NH). At 2 mo of age, visceromotor responses to graded intensities of phasic colorectal...
متن کاملFetal response to induced maternal stress.
BACKGROUND Despite increased attention to the role of antenatal maternal psychological stress in postnatal development, remarkably little information is available on the nature of the intrauterine fetal response to maternal psychological state. AIMS To determine whether: (1) the fetus responds to maternal stress; (2) the fetal response changes over gestation; and (3) individual maternal and f...
متن کاملMaternal Separation Induced Visceral Hypersensitivity from Childhood to Adulthood
Background/Aims Early adverse life events (EALs) are relevant to irritable bowel syndrome in adulthood. Maternal separation (MS), as one of the EALs, has proved to induce visceral hypersensitivity in adult rats. However, the effect of MS on visceral hypersensitvity from the post-weaning period to adulthood remains unknown. Methods One hundred and ten neonatal Sprague-Dawley rats were randomly...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12183-z